Clegg and Cameron: letter to colleagues. Photograph: Andy Rain/EPA David Cameron and Nick Clegg have written to cabinet colleagues to remind them that reducing the deficit is the “most urgent issue facing Britain”. The prime minister and his deputy said they thought it would be... 

Avandia was one of Glaxo’s blockbuster drugs. Photograph: Paul Sakuma/AP GlaxoSmithKline was the biggest faller in the FTSE 100 today after British medical experts demanded that Avandia, its controversial diabetes pill, be withdrawn from sale in the UK. Avandia’s side effects have... 

Kane & Lynch 2 … ups the intensity and gore quotient considerably A former mercenary and a self-medicating psychopath respectively, Kane and Lynch return for a second slice of grisly, gun-heavy entertainment. Buy it from PS3 PC XBox 360 Kane and Lynch 2: Dog Days – Limited... 

Amazon has launched a UK ebook store for users of its Kindle Amazon today launched its UK Kindle Store, with more than 400,000 ebooks now available to download. The price and scope of the digitised books marks a significant point in Amazon’s move towards domination in the ebooks market. Up...